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`!Coronin, actin binding protein, 2A`! is a `F33f`_`[protein`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Protein]`_`f that in humans is encoded by the CORO2A `F33f`_`[gene`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Gene]`_`f.`:cite-ref-entrez-5-0[`F5bf`_`[5`#cite-note-entrez-5]`_`f]

This gene encodes a member of the `F33f`_`[WD repeat`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=WD_repeat]`_`f protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].`:cite-ref-entrez-5-1[`F5bf`_`[5`#cite-note-entrez-5]`_`f]

>>Contents

• `F0af`_`[References`#references]`_`f

• `F0af`_`[External links`#external-links]`_`f

• `F0af`_`[Further reading`#further-reading]`_`f

-─

>>References

`:cite-note-refgrch38ensembl-1`!1.`! GRCh38: Ensembl release 89: ENSG00000106789 – `F33f`_`[Ensembl`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Ensembl_genome_database_project]`_`f, May 2017

`:cite-note-refgrcm38ensembl-2`!2.`! GRCm38: Ensembl release 89: ENSMUSG00000028337 – `F33f`_`[Ensembl`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Ensembl_genome_database_project]`_`f, May 2017

`:cite-note-3`!3.`! "Human PubMed Reference:". `*National Center for Biotechnology Information, U.S. National Library of Medicine`*.

`:cite-note-4`!4.`! "Mouse PubMed Reference:". `*National Center for Biotechnology Information, U.S. National Library of Medicine`*.

`:cite-note-entrez-5`!5.`! `F0af`_`[↑`#cite-ref-entrez-5-0]`_`f "Entrez Gene: Coronin, actin binding protein, 2A". Retrieved 2012-01-03.

>>External links

• Human `*CORO2A`* genome location and `*CORO2A`* gene details page in the `F33f`_`[UCSC Genome Browser`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=UCSC_Genome_Browser]`_`f.

>>Further reading

• `:citerefyoonchanhuangli2003`aYoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". `*The EMBO Journal`*. `!22`! (6): 1336–46. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1093/emboj/cdg120. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 151047. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 12628926.

• `:citerefyoonchanreynoldsqin2003`aYoon HG, Chan DW, Reynolds AB, Qin J, Wong J (September 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". `*Molecular Cell`*. `!12`! (3): 723–34. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1016/j.molcel.2003.08.008. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 14527417.

• `:citerefmarshallaloorbear2009`aMarshall TW, Aloor HL, Bear JE (September 2009). "Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway". `*Journal of Cell Science`*. `!122`! (Pt 17): 3061–9. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1242/jcs.051482. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 2729258. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 19654210.

• `:citerefjinbirleafainmailloux2010`aJin Y, Birlea SA, Fain PR, Mailloux CM, Riccardi SL, Gowan K, Holland PJ, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA (July 2010). "Common variants in FOXP1 are associated with generalized vitiligo". `*Nature Genetics`*. `!42`! (7): 576–8. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1038/ng.602. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 2893242. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 20526340.

• `:citerefzaphiropoulostoftg-rd1996`aZaphiropoulos PG, Toftgård R (December 1996). "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region". `*DNA and Cell Biology`*. `!15`! (12): 1049–56. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1089/dna.1996.15.1049. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 8985118.

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